Genetic Testing Options


Screening for risk of Down syndrome (Trisomy 21), Trisomy 18, and Trisomy 13

Invasive tests: amniocentesis and CVS; these are the most accurate tests and considered diagnostic.

Non-invasive screening tests:

  • Cell-free DNA (maternal blood test)
    • Detection rate of 99% with a less 1% false positive rate
  • First trimester screen (US and maternal blood test)
    • Detection rate of 85% with a 5% false positive rate

If there is a positive screen, further testing may be recommended, such as invasive tests, Level 2 US, or MFM referral. This screening is recommended during each pregnancy.

May–Grant Recommends these screening tests:

  • Ultrasound at 12-13.6 weeks gestation
  • Cell-free DNA testing (NIPS) at the same time. If the testing is cost prohibitive, blood work for the 1st trimester screen can be done instead. If you are pregnant with twins, we may recommend the first trimester screen blood work instead of the NIPS.

Genetic Carrier Screening:

A genetic carrier is an individual who usually shows no signs of a genetic disease but may pass those genes on to a child. If that child is conceived with a partner who is also a carrier for the same genetic disorder, the child may be at high risk to have the disease. The likelihood of having a positive test result increases as more conditions are tested for, however, the chances of conceiving a child with the disease are still low.

This screening is generally a one-time screening which can be done anytime (ideally before pregnancy). If new mutations are identified in the future, new testing could be recommended. If there is a positive result, a referral to genetic counseling will be made.

Insurance coverage may vary, so please discuss anticipated coverage and out-of-pocket costs with your insurance company.


  • Non-Invasive prenatal screen (NIPS) / cell-free DNA
  • Carrier Screening
  • First trimester screen:
    76813 (ultrasound portion – single baby)
    76814 (ultrasound portion – twins)

Genetic Testing Options

Accepted Insurances

May-Grant Obstetrics & Gynecology participates with the following insurances. Please note that office copays are due at the time of service and any co-insurances are the responsibility of the patient. Please check with your carrier or call our office at 717-397-8177 for an updated menu of insurance options.

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January, 2023

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